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Insulin-like growth factor
From Proteopedia
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<StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''> | <StructureSection load='1gzr' size='400' side='right' caption='Structure of insulin-like growth factor I complex with detergent (PDB entry [[1gzr]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme.<br /> | + | '''Insulin-like growth factor''' (IGF) are proteins with high sequence similarity to insulin. IGF are ligands in a complex called the IGF axis, which contains 2 IGF receptors, 6 IGF-binding proteins and IGF-binding protein degrading enzyme<ref>PMID:15797461</ref>.<br /> |
* '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br /> | * '''IGF I''' is secreted in the liver after stimulation by growth hormone.<br /> | ||
* '''IGF II''' is required in early development stages. | * '''IGF II''' is required in early development stages. | ||
| + | |||
| + | == Relevance == | ||
| + | Inhibition of IGF I influences colon cancer<ref>PMID:11694656</ref>. IGF I has protective effect in neuropathy<ref>PMID:15832492</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:51, 29 March 2016
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3D structures of insulin-like growth factor
Updated on 29-March-2016
