Insulin receptor
From Proteopedia
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<StructureSection load='3bu5' size='400' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry [[3bu5]])' scene=''> | <StructureSection load='3bu5' size='400' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (green), Mg+2 ion (green) and ATP (stick model) (PDB entry [[3bu5]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, | + | '''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, insulin-like growth factor I and II<ref>PMID:8141246</ref>. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK). For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-1]].<br /> |
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| + | == Disease == | ||
| + | IR is important for the regulation of glucose homeostasis and its malfunction can cause diabetics and cancer. IR is overexpressed in cancer<ref>PMID:18465356</ref>. | ||
See also [[Insulin Receptor - kinase domain (hebrew)]]. | See also [[Insulin Receptor - kinase domain (hebrew)]]. | ||
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[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | [[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | ||
[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS | [[1rqq]] – hIR TK domain (mutant) + adaptor protein PS | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:25, 29 March 2016
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