Hemagglutinin-esterase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 5: Line 5:
== Structural highlights ==
== Structural highlights ==
-
The biological assmebly of HE is a <scene name='48/484851/Cv/2'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/3'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/5'>Acetylated sialic acid binding site</scene>. HE contains a conserved metal-binding site<ref>PMID:22291594</ref>.
+
The biological assmebly of HE is a <scene name='48/484851/Cv/2'>dimer</scene> and each monomer contains <scene name='48/484851/Cv/3'>3 domains: the membrane fusion domain, the esterase domain and the receptor-binding domain</scene>. The receptor binding site of HE is located at five exposed surface loops. <scene name='48/484851/Cv/5'>Acetylated sialic acid binding site</scene>. HE contains a <scene name='48/484851/Cv/6'>conserved metal-binding site</scene><ref>PMID:22291594</ref>.
</StructureSection>
</StructureSection>
==3D structures of hemagglutinin-esterase==
==3D structures of hemagglutinin-esterase==

Revision as of 11:35, 29 March 2016

Pig torovirus glycosylated hemagglutinin-esterase glycoprotein complex with receptor and acetate 3i1l

Drag the structure with the mouse to rotate

3D structures of hemagglutinin-esterase

Updated on 29-March-2016

3cl4 – bHE – bovine
3cl5 – bHE (mutant) + receptor
3i1k – PtHE (mutant) – porcine torovirus
3i1l – PtHE (mutant) + receptor
3i26 – BtHE – bovine torovirus
3i27 – BtHE + receptor
4c7l – mhvHE (mutant) – murine hepatitis virus
4c7w – mhvHE (mutant) + receptor

References

  1. ↑ de Groot RJ. Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses. Glycoconj J. 2006 Feb;23(1-2):59-72. PMID:16575523 doi:http://dx.doi.org/10.1007/s10719-006-5438-8
  2. ↑ Langereis MA, Zeng Q, Heesters BA, Huizinga EG, de Groot RJ. The murine coronavirus hemagglutinin-esterase receptor-binding site: a major shift in ligand specificity through modest changes in architecture. PLoS Pathog. 2012 Jan;8(1):e1002492. doi: 10.1371/journal.ppat.1002492. Epub 2012, Jan 26. PMID:22291594 doi:http://dx.doi.org/10.1371/journal.ppat.1002492

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Hemagglutinin-esterase"
Personal tools