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Neurotensin

is a 13-amino acid peptide originally isolated from bovine hypothalamus. It fulfills the role of both a neurotransmitter and a neuromodulator in the nervous system and a hormone in the periphery. NTS is a neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It is also a paracrine and endocrine modulator in the periphery of the digestive tract and cardiovascular system. Finally, NTS serves as a growth factor for many normal and cancerous cell types.(Vincent)

Only the C-terminal tail of NTS, amino acids 8-13, were resolved in the crystal structure.

Binding Site

Binding of NTS to the binding site is enriched by between the positive NTS arginine side chains and the electronegative pocket. In addition, the C-terminus forms a with R327.

Function

Disease

Relevance

Structural highlights

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