1h30
From Proteopedia
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|PDB= 1h30 |SIZE=350|CAPTION= <scene name='initialview01'>1h30</scene>, resolution 2.2Å | |PDB= 1h30 |SIZE=350|CAPTION= <scene name='initialview01'>1h30</scene>, resolution 2.2Å | ||
|SITE= <scene name='pdbsite=CAA:So4+Binding+Site+For+Chain+A'>CAA</scene> | |SITE= <scene name='pdbsite=CAA:So4+Binding+Site+For+Chain+A'>CAA</scene> | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h30 OCA], [http://www.ebi.ac.uk/pdbsum/1h30 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h30 RCSB]</span> | ||
}} | }} | ||
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[[Category: Tisi, D.]] | [[Category: Tisi, D.]] | ||
[[Category: Ullrich, A.]] | [[Category: Ullrich, A.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: SO4]] | ||
[[Category: axl/sky/mer ligand]] | [[Category: axl/sky/mer ligand]] | ||
[[Category: calcium-binding]] | [[Category: calcium-binding]] | ||
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[[Category: vitamin k-dependent protein]] | [[Category: vitamin k-dependent protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:56:41 2008'' |
Revision as of 17:56, 30 March 2008
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| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6
Overview
Receptor tyrosine kinases of the Axl family are activated by Gas6, the product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated in cell survival, adhesion, and migration. The receptor-binding site of Gas6 is located within a C-terminal pair of laminin G-like (LG) domains that do not resemble any other receptor tyrosine kinase ligand. We report the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG domains strengthened by an interdomain calcium-binding site. LG2 of Gas6-LG contains two unusual features: an alpha-helix cradled by one edge of the LG beta-sandwich and a conspicuous patch of surface-exposed hydrophobic residues. Mutagenesis of some residues in this patch reduces Gas6-LG binding to the extracellular domain of Axl as well as Axl activation in glioblastoma cells, identifying a component of the receptor-binding site of Gas6.
About this Structure
1H30 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:12218057
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