Interferon receptor
From Proteopedia
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<StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''> | <StructureSection load='3s9d' size='350' side='right' caption='Structure of interferon α/β receptor β chain ectodomain (green and yellow) complex with interferon-α 2 (grey and pink) and Cl- ion (green) (PDB entry [[3s9d]])' scene=''> | ||
| - | + | == Function == | |
'''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br /> | '''Interferon receptor''' (IFNR) is a cell surface receptor which binds interferon.<br /> | ||
* '''Interferon α/β receptor''' binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2<ref>PMID:17969444</ref>. For more details see [[IFNAR]] and [[Multiple sclerosis]].<br /> | * '''Interferon α/β receptor''' binds interferon-α and interferon-β. It is a heterodimer with subunits INFAR1 and INFAR2<ref>PMID:17969444</ref>. For more details see [[IFNAR]] and [[Multiple sclerosis]].<br /> | ||
* '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br /> | * '''Interferon γ receptor''' binds interferon-γ and is a heterodimer with subunits INFGR1 and INFGR2<ref>PMID:9462485</ref>.<br /> | ||
* '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>. | * '''Interferon δ receptor''' binds interferon-δ<ref>PMID:9865499</ref>. | ||
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| + | == Relevance == | ||
| + | Lack of neuronal interferon α/β receptor causes Lewy Body and Parkinson-like dementia in mice<ref>PMID:16451483</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:47, 30 March 2016
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3D structures of interferon receptor
Updated on 30-March-2016
References
- ↑ Uze G, Schreiber G, Piehler J, Pellegrini S. The receptor of the type I interferon family. Curr Top Microbiol Immunol. 2007;316:71-95. PMID:17969444
- ↑ Pestka S, Kotenko SV, Muthukumaran G, Izotova LS, Cook JR, Garotta G. The interferon gamma (IFN-gamma) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 1997 Sep;8(3):189-206. PMID:9462485
- ↑ Lefevre F, Guillomot M, D'Andrea S, Battegay S, La Bonnardiere C. Interferon-delta: the first member of a novel type I interferon family. Biochimie. 1998 Aug-Sep;80(8-9):779-88. PMID:9865499
- ↑ . PMID:16451483
