Interferon regulatory factor
From Proteopedia
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<StructureSection load='1if1' size='400' side='right' caption='Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry [[1if1]])' scene=''> | <StructureSection load='1if1' size='400' side='right' caption='Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry [[1if1]])' scene=''> | ||
| - | '''Interferon regulatory factor''' (IRF) regulate transcription of interferons.<br /> | + | '''Interferon regulatory factor''' (IRF) regulate transcription of interferons<ref>PMID:17399883</ref>.<br /> |
| - | * '''IRF-1''' functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter.<br /> | + | * '''IRF-1''' functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter<ref>PMID:15226432</ref>.<br /> |
| - | * '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors.<br /> | + | * '''IRF-3''' and '''IRF-7''' are activated by viruses or after binding to Toll-like receptors<ref>PMID:9488451</ref>.<br /> |
| - | * '''IRF-4''' is lymphoid-specific and functions in the development of immune cells. | + | * '''IRF-4''' is lymphoid-specific and functions in the development of immune cells<ref>PMID:23980171</ref>. |
</StructureSection> | </StructureSection> | ||
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**[[3qu3]] - mIRF DNA binding domain | **[[3qu3]] - mIRF DNA binding domain | ||
}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Revision as of 08:17, 30 March 2016
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3D structures of interferon regulatory factor
Updated on 30-March-2016
References
- ↑ Paun A, Pitha PM. The IRF family, revisited. Biochimie. 2007 Jun-Jul;89(6-7):744-53. Epub 2007 Feb 20. PMID:17399883 doi:http://dx.doi.org/10.1016/j.biochi.2007.01.014
- ↑ Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 2004 Jul;24(14):6298-310. PMID:15226432 doi:http://dx.doi.org/10.1128/MCB.24.14.6298-6310.2004
- ↑ Weaver BK, Kumar KP, Reich NC. Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. Mol Cell Biol. 1998 Mar;18(3):1359-68. PMID:9488451
- ↑ Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Hocker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrucker HW, Huber M. The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi:, 10.1073/pnas.1309378110. Epub 2013 Aug 26. PMID:23980171 doi:http://dx.doi.org/10.1073/pnas.1309378110
