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1h4u
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h4u OCA], [http://www.ebi.ac.uk/pdbsum/1h4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h4u RCSB]</span> | ||
}} | }} | ||
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[[Category: extracellular matrix protein]] | [[Category: extracellular matrix protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:57:49 2008'' |
Revision as of 17:57, 30 March 2008
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| , resolution 2.20Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DOMAIN G2 OF MOUSE NIDOGEN-1
Overview
Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. Here, we report the crystal structure of the mouse nidogen-1 G2 fragment, which contains binding sites for collagen IV and perlecan. The structure is composed of an EGF-like domain and an 11-stranded beta-barrel with a central helix. The beta-barrel domain has unexpected similarity to green fluorescent protein. A large surface patch on the beta-barrel is strikingly conserved in all metazoan nidogens. Site-directed mutagenesis demonstrates that the conserved residues are involved in perlecan binding.
About this Structure
1H4U is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure and mutational analysis of a perlecan-binding fragment of nidogen-1., Hopf M, Gohring W, Ries A, Timpl R, Hohenester E, Nat Struct Biol. 2001 Jul;8(7):634-40. PMID:11427896
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