Sandbox Reserved 428

Introduction

What to talk about:
What class of proteins it belongs to, how its characterized, other names
-Nuclear hormone receptor
-Component of Mediator complex
Basic function
-transcription regulator of hormone sensitive genes
-has central role in calcium homeostasis
Retailed Diseases
-Rickets, hypocalcemia, secondary hyperparathyroidism, total alopecia
Importance

Overall Structure

Diagram of Protein Protein indicates alpha helices, while yellow indicates beta sheets: Outline: -Discuss Primary Structure[ -Discuss Secondary Structure -Comprised of alpha helices and 1 beta sheet -Discuss tertiary structure -No quaternary structure -427 amino acids, 48289 Da (http://www.genecards.org/cgi-bin/carddisp.pl?gene=VDR)

The vitamin d receptor contains 427 amino acids with a total molecular weight of 48,289 Da [

Binding Interactions

Protein 1db1 is found to complex with 1,25 Dihydroxy . This molecule has three notable alcohol groups that have the ability to participate in interactions with the protein. Vitamin D3 has a large number of relations with the residues on the protein chain. First in the sequence are . Tyr143, shown in blue, is the closest to the ligand at 2.83 angstroms. This is sightly large but there is still the possibility of hydrogen bonding. Tyr147 in green and Phe150 in black are also known to have interactions with Vitamin D3 they are farther away and therefore less significant. Outline: as has been started, the interactions of the various residues will be covered. The types of bonds that 1db1 and VDX form will be elaborated as well

Additional Features

A mutation in the transcription of the protein has the potential to result in the disease known as type 2 rickets. The mutation results in the not forming properly. Therefore VDR cannot complex with VDX. Outline: -Discuss mutations in Vitamin D receptor (Rickets) -Regulating hair cycle -Examine attempts to regulate Vitamin D receptor

Quiz Question 1

Quiz question: More information is needed to focus what the quiz should be about. Possibly related to how the secondary structure is comprised almost entirely of alpha helices, and how that relates to the amino acid sequences.

See Also

• 3w0a
• 3w0c
• 3w0y
• 3w5t
• 3w5r
• 1db1

Credits

Introduction - Kate Daborowski

Overall Structure - Aaron Thole and Benjamin Rizkin

Drug Binding Site - Roger Crocker

Additional Features - Patrick Murphy

Quiz Question 1 - name of team member

References

1. ↑ Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell. 2000 Jan;5(1):173-9. PMID:10678179