Isopentenyl-diphosphate delta-isomerase

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<StructureSection load='2zry' size='340' side='right' caption='Structure of isopentenyl-diphosphate delta-isomerase complex with FMN, Mg+2 ion (green) and IPP (PDB code [[2zry]]).' scene=''>
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<StructureSection load='1nfz' size='340' side='right' caption='Structure of isopentenyl-diphosphate delta-isomerase complex with FMN, Mg+2 ion (green) and IPP (PDB code [[2zry]]).' scene=''>
== Function ==
== Function ==
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'''Isopentenyl-diphosphate delta-isomerase''' (IPPI) catalyzes the conversion of the un-reactive isopentenyl diphosphate (IPP) to the more reactive dimethylallyl diphosphate (DMAPP). 3,4-epoxy-3-methyl butyl diphosphate (EIPP) is an irreversible inhibitor of IPPI. IPPI participates in isoprenoid biosynthesis.
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'''Isopentenyl-diphosphate delta-isomerase''' (IPPI) catalyzes the conversion of the un-reactive isopentenyl diphosphate (IPP) to the more reactive dimethylallyl diphosphate (DMAPP). 3,4-epoxy-3-methyl butyl diphosphate (EIPP) is an irreversible inhibitor of IPPI. IPPI participates in isoprenoid biosynthesis<ref>PMID:3022798</ref>.
== Disease ==
== Disease ==

Revision as of 08:58, 3 April 2016

Structure of isopentenyl-diphosphate delta-isomerase complex with FMN, Mg+2 ion (green) and IPP (PDB code 2zry).

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3D structures of isopentenyl-diphosphate delta-isomerase

Updated on 03-April-2016

References

  1. Reardon JE, Abeles RH. Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. Biochemistry. 1986 Sep 23;25(19):5609-16. PMID:3022798

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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