Isopropylmalate dehydrogenase
From Proteopedia
(Difference between revisions)
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<StructureSection load='3vl2' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | <StructureSection load='3vl2' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Isopropylmalate dehydrogenase''' (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses [[NAD]] as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation<ref>PMID: | + | '''3-Isopropylmalate dehydrogenase''' (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses [[NAD]] as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation<ref>PMID:17979826</ref>. |
== Structural highlights == | == Structural highlights == | ||
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**[[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' | **[[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' | ||
| - | *2-isopropylmalate dehydrogenase | ||
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| - | **[[3fig]] - MtIMDH (mutant) + Zn | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:44, 3 April 2016
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3D structures of isopropylmalate dehydrogenase
Updated on 03-April-2016
References
- ↑ Martignon S, Rossi F, Rizzi M. Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB). Protein Pept Lett. 2007;14(8):822-7. PMID:17979826
