Isopropylmalate isomerase
From Proteopedia
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| - | <StructureSection load='1v7l' size='340' side='right' caption=' | + | <StructureSection load='1v7l' size='340' side='right' caption='3-isopropylmalate isomerase small subunit (PDB code [[1v7l]])' scene=''> |
== Function == | == Function == | ||
| - | '''Isopropylmalate isomerase''' (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate | + | '''Isopropylmalate isomerase''' (IPMI) catalyzes a stereo-specific isomerization of 3-isopropylmalate by dehydration followed by rehydration at a different position to 2-isopropylmalate. IPMI is a homodimer composed of a large subunit (LeuC) and a small subunit (LeuD)<ref>PMID:15522288</ref>. |
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</StructureSection> | </StructureSection> | ||
Revision as of 06:44, 4 April 2016
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3D structures of Isopropylmalate isomerase
Updated on 04-April-2016
1v7l – PhIPMI small subunit – Pyrococcus horikoshii
2hcu – SmIPMI small subunit – Streptococcus mutans
3q3w – CjIPMI small subunit – Campylobacter jejuni
3vba – MjIPMI small subunit – Methanocaldococcus janaschii
4kp1, 4nqy – MjIPMI large subunit
3h5e, 5h5h, 5h5j – MtIPMI small subunit – Mycobacterium tuberculosis
References
- ↑ Yasutake Y, Yao M, Sakai N, Kirita T, Tanaka I. Crystal structure of the Pyrococcus horikoshii isopropylmalate isomerase small subunit provides insight into the dual substrate specificity of the enzyme. J Mol Biol. 2004 Nov 19;344(2):325-33. PMID:15522288 doi:10.1016/j.jmb.2004.09.035
