Kallikrein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Kallikrein''' (KLK) is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin. | + | '''Kallikrein''' (KLK) is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin<ref>PMID:19689262</ref>. |
== Disease == | == Disease == | ||
| - | + | Activation of KLK pathway may contribute to diabetic macular edema<ref>PMID:20535647</ref>. | |
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| + | KLK being a serine protease contains the Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole<ref>PMID:16950394</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:03, 5 April 2016
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3D Structures of kallikrein
Updated on 05-April-2016
References
- ↑ Bryant JW, Shariat-Madar Z. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234-50. PMID:19689262
- ↑ Feener EP. Plasma kallikrein and diabetic macular edema. Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1. PMID:20535647 doi:http://dx.doi.org/10.1007/s11892-010-0127-1
- ↑ Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003
