Kelch-like protein
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='4ifl' size='340' side='right' caption='Human Kelch-like protein19 (Keap1) Kelch domain (dark green) complex with NRF2 Neh2 peptide (light green) (PDB code [[4ifl]])' scene=''> | <StructureSection load='4ifl' size='340' side='right' caption='Human Kelch-like protein19 (Keap1) Kelch domain (dark green) complex with NRF2 Neh2 peptide (light green) (PDB code [[4ifl]])' scene=''> | ||
| - | '''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to Eight such blades form a circular β-propeller domain. β-prepellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions. | ||
| - | |||
== Function == | == Function == | ||
| + | '''Kelch-like proteins''' (KLHL) contain multiple Kelch motifs. This motif is about 50 residues long and forms a four-stranded β-sheet blade. Six to Eight such blades form a circular β-propeller domain. β-prepellers are involved in protein-protein interactions. The N-terminal of KLHL contains other protein domains like BTB (Broad-Tramtrack-Bric-a-brac) which is also involved in protein-protein interactions<ref>PMID:23676014</ref>. | ||
== Disease == | == Disease == | ||
Revision as of 10:08, 5 April 2016
| |||||||||||
3D Structures of Kelch-like protein
Updated on 05-April-2016
References
- ↑ Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. Update on the Kelch-like (KLHL) gene family. Hum Genomics. 2013 May 15;7:13. doi: 10.1186/1479-7364-7-13. PMID:23676014 doi:http://dx.doi.org/10.1186/1479-7364-7-13
