Integrin
From Proteopedia
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| - | <StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''> | + | <StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene='51/516472/Cv/1'> |
== Function == | == Function == | ||
'''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]]. | '''Integrins''' (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle<ref>PMID:10961914</ref>. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see [[Molecular Playground/IntegrinBeta1]]. | ||
Revision as of 11:28, 5 April 2016
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3D structures of integrin
Updated on 05-April-2016
References
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
- ↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
- ↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
- ↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
