Kinesin

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{{STRUCTURE_2zfi | PDB=2zfi | SIZE=350 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }}
{{STRUCTURE_2zfi | PDB=2zfi | SIZE=350 | SCENE=Kinesin/Kinesin_start_scene/2 | CAPTION=Kif1A Motor Domain complex with ADP and Mg+2 ion (green), [[2zfi]] }}
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'''3D Structure of Kinesin''' <br />
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== Function ==
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The image is a Crystal Structure of the Kif1A Motor Domain Before Mg Release ([[2zfi]])
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== Kinesin ==
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[[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.<br />
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*'''Kar3''' is kinesin protein in yeast.<br />
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*'''Eg5''' or '''KIF11''' is a kinesin (See [[Kinesin-5]]) which participates in mitosis.<br />
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*'''KCBP''' is a '''Kinesin-like Calmodulin Binding Protein'''.<br />
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*'''NOD''' is a ''Drosophila'' chromosome-associated kinesin.
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[[Kinesin|Kinesins]] are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition. Kinesin protein in yeast is called '''Kar3'''. '''Eg5''' or '''KIF11''' is a kinesin (See [[Kinesin-5]]) which participates in mitosis. '''KCBP''' is a '''Kinesin-like Calmodulin Binding Protein'''. '''NOD''' is a Drosophila chromosome-associated kinesin. See also [[CAP-Gly domain]].
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See also [[CAP-Gly domain]].
== 3D Structures of Kinesin ==
== 3D Structures of Kinesin ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Kinesin heavy chain (KIF)
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*Kinesin heavy chain
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br />
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**[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
**[[3dco]] - DmNOD catalytic core domain+ cTubulin A+cTubulin B<br />
}}
}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:45, 6 April 2016

Template:STRUCTURE 2zfi

Function

Kinesins are eukaryotic motor proteins which move along microtubules. Kinesin (KIF) is a dimer consisting of 2 heavy chains and two light chains. The heavy chain contains the globular motor domain (MD), flexible neck linker (FNL) and a long coiled-coil stalk which intertwines to form the dimer. The light chain (KLC) forms the tail region. The KLC contains a cargo binding domain which is called TPR (Tetratricopeptide repeat). The KIFs are named by their gene number. KIF contains a forkhead-associated domain (FHA) which is involved in phosphopeptide recognition.

  • Kar3 is kinesin protein in yeast.
  • Eg5 or KIF11 is a kinesin (See Kinesin-5) which participates in mitosis.
  • KCBP is a Kinesin-like Calmodulin Binding Protein.
  • NOD is a Drosophila chromosome-associated kinesin.

See also CAP-Gly domain.

3D Structures of Kinesin

Updated on 06-April-2016

References

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