Alpha-lactalbumin

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{{STRUCTURE_1hml| PDB=1hml | SIZE=400| SCENE= |right|CAPTION=Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions, [[1hml]] }}
{{STRUCTURE_1hml| PDB=1hml | SIZE=400| SCENE= |right|CAPTION=Human α-lactalbumin complex with sulfate, Zn+2 (grey) and Ca+2 (green) ions, [[1hml]] }}
== Function ==
== Function ==
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'''Lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey. It has α (LCAa)<ref>PMID:10818224</ref> and β (LCAb) forms. LCAa is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.
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'''Alpha-lactalbumin''' (LCA) is the albumin contained in milk and obtained from whey<ref>PMID:10818224</ref>. LCA is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.
== Relevance ==
== Relevance ==
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LCAa is tested as a target for potential breast cancer vaccine. LCAb is the major whey protein of cow and sheep milk. LCAb is the target of testing for the presence of milk as an allergen.
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LCA is tested as a target for potential breast cancer vaccine. LCA is the major whey protein of cow and sheep milk. LCA is the target of testing for the presence of milk as an allergen.
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== 3D Structures of lactalbumin ==
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== 3D Structures of α-lactalbumin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Lactalbumin
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*α-lactalbumin
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**[[1alc]] – LCAa – baboon
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**[[1alc]] – LCA – baboon
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**[[1hml]], [[1b9o]], [[3b0i]], [[3b0o]] – hLCAa –human
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**[[1hml]], [[1b9o]], [[3b0i]], [[3b0o]] – hLCA –human
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**[[1a4v]] – hLCAa Ca-binding domain<br />
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**[[1a4v]] – hLCA Ca-binding domain<br />
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**[[1cb3]] – hLCAa residues 1-13 - NMR<br />
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**[[1cb3]] – hLCA residues 1-13 - NMR<br />
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**[[1hfx]] – LCAa – guinea pig
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**[[1hfx]] – LCA – guinea pig
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**[[1hfy]], [[3b0k]] – gLCAa – goat
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**[[1hfy]], [[3b0k]] – gLCA – goat
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**[[1hmk]], [[1fkq]], [[1fkv]] – gLCAa (mutant)
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**[[1hmk]], [[1fkq]], [[1fkv]] – gLCA (mutant)
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**[[1f6r]], [[1f6s]], [[2g4n]] – bLCAa - bovine
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**[[1f6r]], [[1f6s]], [[2g4n]] – bLCA - bovine
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**[[1hfz]] – bLCAa (mutant)
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**[[1hfz]] – bLCA (mutant)
*α-LCA complexes
*α-LCA complexes
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**[[1nf5]] – mLCAa + β-1,4-galactosyl transferase + glucose – mouse
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**[[1nf5]] – mLCA + β-1,4-galactosyl transferase + glucose – mouse
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**[[1nhe]] – mLCAa + β-1,4-galactosyl transferase + UDP
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**[[1nhe]] – mLCA + β-1,4-galactosyl transferase + UDP
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**[[1nkh]] – mLCAa + β-1,4-galactosyl transferase + UDP + Mn
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**[[1nkh]] – mLCA + β-1,4-galactosyl transferase + UDP + Mn
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**[[1nmm]] – mLCAa + β-1,4-galactosyl transferase (mutant)
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**[[1nmm]] – mLCA + β-1,4-galactosyl transferase (mutant)
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**[[1nqi]] - mLCAa + β-1,4-galactosyl transferase
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**[[1nqi]] - mLCA + β-1,4-galactosyl transferase
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**[[1nwg]] - mLCAa + β-1,4-galactosyl transferase + butanoyl-glucosamine
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**[[1nwg]] - mLCA + β-1,4-galactosyl transferase + butanoyl-glucosamine
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**[[1o23]] - mLCAa + β-1,4-galactosyl transferase + UDP-glucose
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**[[1o23]] - mLCA + β-1,4-galactosyl transferase + UDP-glucose
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**[[1oqm]] - mLCAa + β-1,4-galactosyl transferase + UDP-acetyl-galactosamine
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**[[1oqm]] - mLCA + β-1,4-galactosyl transferase + UDP-acetyl-galactosamine
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**[[1pzy]] - mLCAa (mutant) + β-1,4-galactosyl transferase + acetyl-glucosamine + UDP + Mn
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**[[1pzy]] - mLCA (mutant) + β-1,4-galactosyl transferase + acetyl-glucosamine + UDP + Mn
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**[[1yro]] - mLCAa + β-1,4-galactosyl transferase + UDP-galactose + Mn
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**[[1yro]] - mLCA + β-1,4-galactosyl transferase + UDP-galactose + Mn
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**[[1fyc]] - mLCAa (mutant) + β-1,4-galactosyl transferase + UDP-galactose + Ca
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**[[1fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + UDP-galactose + Ca
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**[[2fyd]], [[2fyc]] - mLCAa (mutant) + β-1,4-galactosyl transferase + glucose + UDP-acetylgalactosamine + Mn<br />
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**[[2fyd]], [[2fyc]] - mLCA (mutant) + β-1,4-galactosyl transferase + glucose + UDP-acetylgalactosamine + Mn<br />
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**[[4l41]] - hLCAa + β-1,4-galactosyl transferase (mutant)<br />
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**[[4l41]] - hLCA + β-1,4-galactosyl transferase (mutant)<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:19, 7 April 2016

Template:STRUCTURE 1hml

Contents

Function

Alpha-lactalbumin (LCA) is the albumin contained in milk and obtained from whey[1]. LCA is the regulatory subunit of the lactose synthase heterodimer which produces lactose by transferring galactose moieties to glucose.

Relevance

LCA is tested as a target for potential breast cancer vaccine. LCA is the major whey protein of cow and sheep milk. LCA is the target of testing for the presence of milk as an allergen.


3D Structures of α-lactalbumin

Updated on 07-April-2016

References

  1. ↑ Permyakov EA, Berliner LJ. alpha-Lactalbumin: structure and function. FEBS Lett. 2000 May 19;473(3):269-74. PMID:10818224

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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