User:Giavanna Verdi/Sandbox1

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== Introduction ==
== Introduction ==
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Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is a type of [[hydrolase]] (an enzyme class that includes [[lipase]]) that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>.
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Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is a type of [[hydrolase]] (an enzyme class that includes [[lipase]]) that is responsible for initiating the digestion of dietary fats in the stomach <ref name="armand">PMID:7598069</ref>. This enzyme is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults <ref name="armand" />.

Revision as of 21:18, 8 April 2016

Structure of Human Gastric Lipase (PDB input: 1HLG)

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Hydrophobic and Hydrophilic Regions of Human Gastric Lipase

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Secondary Structure of Human Gastric Lipase

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This is a default text for your page Giavanna Verdi/Sandbox1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Contents

Introduction

Human gastric lipase (HGL, E.C. 3.1.1.3) (PBD ID: 1hlg) is a type of hydrolase (an enzyme class that includes lipase) that is responsible for initiating the digestion of dietary fats in the stomach [3]. This enzyme is secreted by the fundic chief cells of the human stomach and catalyzes 10-20% of total lipolytic processes (i.e., those involving fat breakdown) in healthy adults [3].


Function

Disease

Relevance

Structural highlights

HGL, a 379 amino acid residue-long lipase enzyme, possesses a catalytic arm consisting of residues Ser-153, His-353, and Asp-324 [4].

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</StructureSection>

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ 3.0 3.1 Armand M, Hamosh M, DiPalma JS, Gallagher J, Benjamin SB, Philpott JR, Lairon D, Hamosh P. Dietary fat modulates gastric lipase activity in healthy humans. Am J Clin Nutr. 1995 Jul;62(1):74-80. PMID:7598069
  4. ↑ Roussel A, Canaan S, Egloff MP, Riviere M, Dupuis L, Verger R, Cambillau C. Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest. J Biol Chem. 1999 Jun 11;274(24):16995-7002. PMID:10358049

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Giavanna Verdi

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