XPD Helicase (3CRV)
From Proteopedia
| Line 2: | Line 2: | ||
<Structure load='3CRV' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='3CRV' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
== Function == | == Function == | ||
| + | -Required for nucleotide excision repair (NER) as part as transcription factor/repair complex TFIIH | ||
| + | -Critical for helicase activity and stability and the TFIIH complex | ||
| + | -DNA helicase is essential during DNA replication because it unwinds the two strands at places called origins, where synthesis is initiated. This allows both strands of DNA to be replicated. | ||
| + | XPD helicase activity is essential for NER but dispensable for transcription | ||
| + | -NER removes DNA damaged by ultraviolet light | ||
== Disease == | == Disease == | ||
Xeroderma Pigmentosum(XP) | Xeroderma Pigmentosum(XP) | ||
Revision as of 16:50, 10 April 2016
Contents |
XPD Helicase
|
Function
-Required for nucleotide excision repair (NER) as part as transcription factor/repair complex TFIIH -Critical for helicase activity and stability and the TFIIH complex -DNA helicase is essential during DNA replication because it unwinds the two strands at places called origins, where synthesis is initiated. This allows both strands of DNA to be replicated. XPD helicase activity is essential for NER but dispensable for transcription -NER removes DNA damaged by ultraviolet light
Disease
Xeroderma Pigmentosum(XP)
Cockayne Syndrome combined with XP (XP/CS)
Trichothiodystrophy(TTD)
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., and Tainer, J. A. (2008) XPD helicase structures and activities: Insights into the cancer and aging phenotypes from XPD mutations.
Proteopedia Page Contributors and Editors (what is this?)
Matt Kohler, Bashir Noor, Chih Hao Huang, Michal Harel, Mark Heslin, Shane Devlin
