Sandbox Reserved 427

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==Additional Features==
==Additional Features==
=====Actin Binding Interactions=====
=====Actin Binding Interactions=====
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The most well documented auxiliary function of Vitamin D binding protein is its ability to bind and sequester circulating actin monomers. [4] The actin interaction occur at the sites shown in <scene name=’48/483884/Dbp_actin_binding_site/1’>red</scene>. While the vitamin D binding domain resides between leucine 35 and serine 49, the actin binding domain lies far away in sequence, between glycine 373 and glycine 403, the site is <scene name=’48/483884/Dbp_actin_dbinding_distance/1'>relatively close</scene> in the folded protein, with residues serine 42 and lysine 388 only 21.44Å apart on complementary subunits or 43.58Å apart on the same subunit.
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The most well documented auxiliary function of Vitamin D binding protein is its ability to bind and sequester circulating actin monomers. [4] The actin interaction occur at the sites shown in <scene name='48/483884/Dbp_actin_binding_site/2'>red</scene>. While the vitamin D binding domain resides between leucine 35 and serine 49, the actin binding domain lies far away in sequence, between glycine 373 and glycine 403, the site is <scene name='48/483884/Dbp_actin_dbinding_distance/1'>much closer</scene> in the folded protein, with residues serine 42 and lysine 388 only 21.44Å apart on complementary subunits or 43.58Å apart on the same subunit.
At the level of the organism, this actin binding of DBP is an important mechanism for clearing actin from necrotic or apoptotic tissue [1]. This actin binding quality serves to prevent clotting and actin toxicity, as large quantities of circulating actin have been shown to be fatal to mice.
At the level of the organism, this actin binding of DBP is an important mechanism for clearing actin from necrotic or apoptotic tissue [1]. This actin binding quality serves to prevent clotting and actin toxicity, as large quantities of circulating actin have been shown to be fatal to mice.

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This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.


Vitamin D binding protein (1j7e)[1]

Alex Debreceni, Robert Green, Uday Prakhya, Nicholas Rivelli, Elizabeth Swanson

Student Projects for UMass Chemistry 423 Spring 2016

caption for Molecular Playground (PDB entry 1j7e)

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