Function
Leucine transporter (LeuT) is a membrane protein which is comprised of 12 transmembrane helices forming a channel. LeuT clears the synapse after signal transduction. LeuT utilizes the electrochemical potential gradient of Na+ ions across the membrane to catalyze the uptake of leucine. The LeuT is a homodimer[1].
Relevance
LeuT is the target of many antidepressant and recreational drugs.
Structural highlights
The leucine binding pocket of LeuT contains 2 Na+ ions[2].
3D structures of leucine transporter
Updated on 11-April-2016
3gwu, 3gwv, 3gww, 2q6h, 2q72, 2qb4, 2qb4, 2qei – AaLeuT + Leu + Na + antidepressant – Aquifex aeolicus
2qju – AaLeuT (mutant) + Leu + Na + Cl + antidepressant
4hod, 4hmk, 3gjd, 3usp – AaLeuT + Leu + Na + halide
3mpn, 3mpq – AaLeuT (mutant) + Leu + Na + halide
3f3e, 3usg, 3usj, 3usi, 3usk – AaLeuT + Leu + Na
4fxz, 3gjc – AaLeuT (mutant) + Leu + Na
3f48, 3f4j, 3f3a, 3f3c, 3f3d, 3f4i – AaLeuT + amino acid + Na
3qs4, 3qs5, 3qs6, 4fy0, 3tu0, 3usl, 3uso, 3usm – AaLeuT (mutant) + amino acid + Na
3tt1 – AaLeuT (mutant) + Na + antibody
3tt3 – AaLeuT (mutant) + antibody
References
- ↑ Tomi M, Mori M, Tachikawa M, Katayama K, Terasaki T, Hosoya K. L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2522-30. PMID:15980244 doi:http://dx.doi.org/10.1167/iovs.04-1175
- ↑ Wang H, Elferich J, Gouaux E. Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat Struct Mol Biol. 2012 Jan 15;19(2):212-9. doi: 10.1038/nsmb.2215. PMID:22245965 doi:10.1038/nsmb.2215
