Leukotriene C4 synthase

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== Structural highlights ==
== Structural highlights ==
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The biological assembly of Human leukotriene C<sub>4</sub> synthase is <scene name='43/433642/Cv/3'>homotrimer</scene>. <scene name='43/433642/Cv/4'>GSH is bound to LTC in a hydrophobic pore between the 2 monomers</scene><ref>PMID:17632546</ref>. <scene name='43/433642/Cv/6'>Active site</scene>. Water molecules shown as red spheres.
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The biological assembly of Human leukotriene C<sub>4</sub> synthase is <scene name='43/433642/Cv/3'>homotrimer</scene>. <scene name='43/433642/Cv/4'>GSH is bound to LTC4S in a hydrophobic pore between the 2 monomers</scene><ref>PMID:17632546</ref>. <scene name='43/433642/Cv/6'>Active site</scene>. Water molecules shown as red spheres.
</StructureSection>
</StructureSection>
== 3D Structures of Leukotriene C4 synthase ==
== 3D Structures of Leukotriene C4 synthase ==

Revision as of 12:32, 13 April 2016

The trimeric human leukotriene C4 synthase in a complex with glutathione sulfonate and palmitic and palmitoleic acids 3hkk

Drag the structure with the mouse to rotate

3D Structures of Leukotriene C4 synthase

Updated on 13-April-2016

2pno, 2uui, 3pcv – hLC4S - human
4nta – mLC4S - mouse
4ntb, 4ntf - mLC4S + glutathione derivative
3leo – hLC4S (mutant)+glutathione
3hkk, 2uuh - hLC4S +glutathione
3b29 – hLC4S + dodecyl-β-D-selenomaltoside
4j7t, 4j7y, 4jcz, 4jrz – hLC4S + product analog
4jc7 – hLC4S (mutant) + product analog

References

  1. ↑ Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7663-7. PMID:8052639
  2. ↑ Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996 May 10;271(19):11356-61. PMID:8626689
  3. ↑ Nicholson DW, Ali A, Klemba MW, Munday NA, Zamboni RJ, Ford-Hutchinson AW. Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. J Biol Chem. 1992 Sep 5;267(25):17849-57. PMID:1517222
  4. ↑ Welsch DJ, Creely DP, Hauser SD, Mathis KJ, Krivi GG, Isakson PC. Molecular cloning and expression of human leukotriene-C4 synthase. Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9745-9. PMID:7937884
  5. ↑ Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7663-7. PMID:8052639
  6. ↑ Martinez Molina D, Wetterholm A, Kohl A, McCarthy AA, Niegowski D, Ohlson E, Hammarberg T, Eshaghi S, Haeggstrom JZ, Nordlund P. Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase. Nature. 2007 Aug 2;448(7153):613-6. Epub 2007 Jul 15. PMID:17632546 doi:10.1038/nature06009


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