User:Madelyn Kasprzak/Sandbox 6
From Proteopedia
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== TET Enzymes== | == TET Enzymes== | ||
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TET enzymes are a family of [[Dioxygenase|dioxygenases]] that are involved in the process of oxidizing methylated cytosine. Members of this family include ten-eleven translocation methylcytosine dioxygenase 1 (TET1), methylcytosine dioxygenase TET2, and methylcytosine dioxygenase TET3. The gene for the first of these proteins, TET1, was identified when it was determined to be fused to the ''Mixed Lineage Leukemia'' (MLL) gene as a result of a translocation event that occurred between chromosomes ten and eleven (hence the name). <ref>DOI 10.1038/sj.leu.2402834</ref> | TET enzymes are a family of [[Dioxygenase|dioxygenases]] that are involved in the process of oxidizing methylated cytosine. Members of this family include ten-eleven translocation methylcytosine dioxygenase 1 (TET1), methylcytosine dioxygenase TET2, and methylcytosine dioxygenase TET3. The gene for the first of these proteins, TET1, was identified when it was determined to be fused to the ''Mixed Lineage Leukemia'' (MLL) gene as a result of a translocation event that occurred between chromosomes ten and eleven (hence the name). <ref>DOI 10.1038/sj.leu.2402834</ref> | ||
| - | == Function == | + | <StructureSection load='5cg9' size='320' side='right' caption='TET-like protein in Naegleria gruberi in complex with DNA containing 5hmC.' scene=''> |
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| + | == Structure and Function == | ||
== Disease == | == Disease == | ||
Revision as of 04:08, 14 April 2016
TET Enzymes
TET enzymes are a family of dioxygenases that are involved in the process of oxidizing methylated cytosine. Members of this family include ten-eleven translocation methylcytosine dioxygenase 1 (TET1), methylcytosine dioxygenase TET2, and methylcytosine dioxygenase TET3. The gene for the first of these proteins, TET1, was identified when it was determined to be fused to the Mixed Lineage Leukemia (MLL) gene as a result of a translocation event that occurred between chromosomes ten and eleven (hence the name). [1]
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References
- ↑ Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003 Mar;17(3):637-41. PMID:12646957 doi:http://dx.doi.org/10.1038/sj.leu.2402834
