User:Madelyn Kasprzak/Sandbox 6
From Proteopedia
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<StructureSection load='5cg9' size='320' side='right' caption='TET-like protein in Naegleria gruberi in complex with DNA containing 5hmC.' scene=''> | <StructureSection load='5cg9' size='320' side='right' caption='TET-like protein in Naegleria gruberi in complex with DNA containing 5hmC.' scene=''> | ||
| - | == Structure | + | == Structure == |
| + | The TET enzymes have a cysteine-rich region closely followed by a double stranded beta-helix (DSBH) domain near their C-terminus.<ref name='Kinney et al.'>DOI 10.1007/978-1-4419-9967-2_3</ref> The DSBH domain contains three Fe<sup>2+</sup> binding sites and an α-ketoglutarate binding site.<ref name='Kinney et al.' /> This DSBH domain, along with the preceding cysteine-rich region, performs the main catalytic activity of these enzymes and more generally, for all α-ketoglutarate oxygenases. | ||
== Disease == | == Disease == | ||
Revision as of 04:09, 14 April 2016
TET Enzymes
TET enzymes are a family of dioxygenases that are involved in the process of oxidizing methylated cytosine. Members of this family include ten-eleven translocation methylcytosine dioxygenase 1 (TET1), methylcytosine dioxygenase TET2, and methylcytosine dioxygenase TET3. The gene for the first of these proteins, TET1, was identified when it was determined to be fused to the Mixed Lineage Leukemia (MLL) gene as a result of a translocation event that occurred between chromosomes ten and eleven (hence the name). [1]
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References
- ↑ Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003 Mar;17(3):637-41. PMID:12646957 doi:http://dx.doi.org/10.1038/sj.leu.2402834
- ↑ 2.0 2.1 Kinney SR, Pradhan S. Ten eleven translocation enzymes and 5-hydroxymethylation in mammalian development and cancer. Adv Exp Med Biol. 2013;754:57-79. doi: 10.1007/978-1-4419-9967-2_3. PMID:22956496 doi:http://dx.doi.org/10.1007/978-1-4419-9967-2_3
