Kelch-like protein

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== Structural highlights ==
== Structural highlights ==
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The interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motif<ref>PMID:16507366</ref>.
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The <scene name='70/706701/Cv/5'>interaction of Keap1 with Neh2 is through the first Glu in the latter's ETGE motifd</scene><ref>PMID:16507366</ref>. <scene name='70/706701/Cv/3'>All interactions of Keap1 with Neh2</scene>. Water molecules shown as red spheres.
</StructureSection>
</StructureSection>

Revision as of 11:29, 14 April 2016

Human Kelch-like protein 1 (Keap1) Kelch domain (cyan) complex with NRF2 Neh2 peptide (green) and sulfate (PDB code 1x2r)

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3D Structures of Kelch-like protein

Updated on 14-April-2016


References

  1. Dhanoa BS, Cogliati T, Satish AG, Bruford EA, Friedman JS. Update on the Kelch-like (KLHL) gene family. Hum Genomics. 2013 May 15;7:13. doi: 10.1186/1479-7364-7-13. PMID:23676014 doi:http://dx.doi.org/10.1186/1479-7364-7-13
  2. Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M. Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell. 2006 Mar 3;21(5):689-700. PMID:16507366 doi:10.1016/j.molcel.2006.01.013

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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