Leukotriene A4 Hydrolase
From Proteopedia
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| - | <StructureSection load='1hs6' size='350' side='right' caption='Human leukotriene A4 Hydrolase complex with bestatin, acetate, imidazole, Yb+3 (green) and Zn+2 (grey) ions (PDB entry [[1hs6]])' scene=''> | + | <StructureSection load='1hs6' size='350' side='right' caption='Human leukotriene A4 Hydrolase complex with bestatin, acetate, imidazole, Yb+3 (green) and Zn+2 (grey) ions (PDB entry [[1hs6]])' scene='43/433034/Cv/1'> |
== Function == | == Function == | ||
[[Leukotriene A4 Hydrolase]] (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism<ref>PMID:24771855</ref> . LTA4H is a bifunctional Zn+2 enzyme. | [[Leukotriene A4 Hydrolase]] (LTA4H) is an aminopeptidase which converts leukotriene A4 to leukotriene B4 as part of the arachidonic acid metabolism<ref>PMID:24771855</ref> . LTA4H is a bifunctional Zn+2 enzyme. | ||
Revision as of 10:35, 17 April 2016
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3D Structures of Leukotriene A4 Hydrolase
Updated on 17-April-2016
References
- ↑ Paige M, Wang K, Burdick M, Park S, Cha J, Jeffery E, Sherman N, Shim YM. Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. J Immunol. 2014 Jun 1;192(11):5059-68. doi: 10.4049/jimmunol.1400452. Epub 2014, Apr 25. PMID:24771855 doi:http://dx.doi.org/10.4049/jimmunol.1400452
- ↑ Fourie AM. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. Curr Opin Investig Drugs. 2009 Nov;10(11):1173-82. PMID:19876785
- ↑ Thunnissen MM, Nordlund P, Haeggstrom JZ. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation. Nat Struct Biol. 2001 Feb;8(2):131-5. PMID:11175901 doi:10.1038/84117
