Mannose-binding protein

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{{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose (stick model) and Ca+2 ion, [[1kzb]] }}
{{STRUCTURE_1kzb| PDB=1kzb | SIZE=400| SCENE= |right|CAPTION=Rat mannose-binding protein fragment complex with mannose (stick model) and Ca+2 ion, [[1kzb]] }}
== Function ==
== Function ==
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'''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:8528769</ref>.
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'''Mannose-binding protein''' (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen<ref>PMID:14666735</ref>.
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== Disease ==
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MBL deficiency is associated with poor outcome of cystic fibrosis patients<ref>PMID:15654829</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 08:11, 18 April 2016

Template:STRUCTURE 1kzb

Contents

Function

Mannose-binding protein (MBL) is a lectin essential to innate immunity. MBL recognizes carbohydrate patterns like mannose or glucose located on the surface of microorganisms like bacteria, viruses and fungi. MBL binds to the microorganism and the activation of the lectin pathway ensues. MBL binds to apoptotic and senescent cells and enhances their engulfment by phagocytes. In the blood, MBL is bound to MBL-associated serine protease (MASP-2). Upon binding of MBL to a target mannose, the MASP initiates the complement cascade resulting in lysis of the pathogen[1].

Disease

MBL deficiency is associated with poor outcome of cystic fibrosis patients[2].

Structural highlights

3D structures of mannose-binding protein

Updated on 18-April-2016

References

  1. ↑ Nakagawa T, Ma BY, Uemura K, Oka S, Kawasaki N, Kawasaki T. Role of mannan-binding protein, MBP, in innate immunity. Anticancer Res. 2003 Nov-Dec;23(6a):4467-71. PMID:14666735
  2. ↑ Carlsson M, Sjoholm AG, Eriksson L, Thiel S, Jensenius JC, Segelmark M, Truedsson L. Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship. Clin Exp Immunol. 2005 Feb;139(2):306-13. PMID:15654829 doi:http://dx.doi.org/10.1111/j.1365-2249.2004.02690.x

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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