Menin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='3u86' size='340' side='right' caption='Structure of human menin complex with piperidine derivative inhibitor, tetraethylene glycol, DMSO and sulfate (PDB code [[4og6]]).' scene=''> |
== Function == | == Function == | ||
| - | '''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD. | + | '''Menin''' (Men) is a putative tumor suppressor. Men possesses two functional nuclear localization signals and inhibits transcriptional activation by JunD<ref>PMID:11524225</ref>. |
== Disease == | == Disease == | ||
| + | Men mutations may be a common mechanism for inactivating tumor suppressor gene products in familial cancer<ref>PMID:15254225</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 08:52, 20 April 2016
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