MEP cytidylyltransferase
From Proteopedia
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== Function == | == Function == | ||
| - | '''MEP cytidylyltransferase''' (MEPCT) catalyzes the conversion of 2C-methyl-D-erythritol 4-phosphate and CTP to 4-(cytidine 5’-diphospho)- 2C-methyl-D-erythritol (CDP-ME) and diphosphate. MEPCT participates in isoprenoid biosynthesis in many bacteria while eukaryotes use the mevalonic acid pathway for the isoprenoed biosynthesis | + | '''MEP cytidylyltransferase''' (MEPCT) catalyzes the conversion of 2C-methyl-D-erythritol 4-phosphate and CTP to 4-(cytidine 5’-diphospho)- 2C-methyl-D-erythritol (CDP-ME) and diphosphate. MEPCT participates in isoprenoid biosynthesis in many bacteria while eukaryotes use the mevalonic acid pathway for the isoprenoed biosynthesis<ref>PMID:11696548</ref>. |
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== Relevance == | == Relevance == | ||
| - | Inhibitors of MEPCT can be used as potential antibiotics. | + | Inhibitors of MEPCT can be used as potential antibiotics<ref>PMID:21694781</ref>. |
== Structural highlights == | == Structural highlights == | ||
| + | The active site of MEPCT contains an Mg+2 ion<ref>PMID:11427897</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:27, 20 April 2016
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3D structures of MEP cytidylyltransferase
Updated on 20-April-2016
References
- ↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
- ↑ Tsang A, Seidle H, Jawaid S, Zhou W, Smith C, Couch RD. Francisella tularensis 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase: kinetic characterization and phosphoregulation. PLoS One. 2011;6(6):e20884. doi: 10.1371/journal.pone.0020884. Epub 2011 Jun 9. PMID:21694781 doi:http://dx.doi.org/10.1371/journal.pone.0020884
- ↑ Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nat Struct Biol. 2001 Jul;8(7):641-8. PMID:11427897 doi:10.1038/89691
