Met repressor
From Proteopedia
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| - | [[Image:1mjo.png|left|200px|thumb|EcMR (mutant) complex with corepressor SAM and DNA [[2eyi]]]] | ||
{{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }} | {{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion (green) and DNA [[1mjo]] }} | ||
| - | + | == Function == | |
| - | + | '''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The coreppressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis<ref>PMID:11696548</ref>. For additional details see<br /> | |
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| - | '''Met repressor''' (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The | + | |
[[Taylor met repressor]]<br /> | [[Taylor met repressor]]<br /> | ||
[[Joe Granger Methionine Repressor: Escherichia coli]]. | [[Joe Granger Methionine Repressor: Escherichia coli]]. | ||
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[[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br /> | [[1mjl]], [[1mjp]] – EcMR (mutant) + SAM<br /> | ||
[[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br /> | [[1mj2]], [[1mjo]], [[1mjq]] – EcMR (mutant) + SAM + DNA<br /> | ||
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| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:37, 20 April 2016
Function
Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The coreppressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis[1]. For additional details see
Taylor met repressor
Joe Granger Methionine Repressor: Escherichia coli.
3D Structures of Met repressor
Updated on 20-April-2016
1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA
References
- ↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
