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<scene name='72/721552/Glucagon_binding_zoomed_in/1'>Glucagon Binding Zoomed in</scene>
<scene name='72/721552/Glucagon_binding_zoomed_in/1'>Glucagon Binding Zoomed in</scene>
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[[Image:ALA135PRO stalk unwinding.png|150 px|left|thumb|Fig. 1: A135P Mutation and effect on stalk stability <ref name= "Siu 2013"/>. ]] [[Image:Gln142 Tyr138 Glucagon interaction.png|150 px|right|thumb|Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.<ref name= "Siu 2013"/>]]
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[[Image:Asn_298__Trp_295.png|150 px|left|thumb|Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled<ref name= "Siu 2013"/>.]]
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[[Image:Corticotropin class B and Glucagon class B receptors aligned.png |150 px|left|thumb|Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay]] [[Image:Beta2 class A and Glucagon class B receptors aligned.png |150 px|right|thumb|Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.]]
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[[Image:Movie_Frame_2.png|100 px|left|thumb|Fig. 7: Active site buried deep in 7TMD of glucagon receptor.]]
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[[Image:Movie Frame 3.png |200 px|right|thumb|Fig. 9: Location of anchoring pocket within central cavity.<ref name= "Siu 2013"/>]]
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[[Image:Movie Frame 6.png |100 px|left|thumb|Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.]]

Revision as of 17:54, 20 April 2016

7TM structure of human class B GPCR 4L6R

Drag the structure with the mouse to rotate

Old Stuff:

Fig. 1: A135P Mutation and effect on stalk stability .
Fig. 1: A135P Mutation and effect on stalk stability [1].
Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.
Fig. 2: Stalk stabilized by salt bridge between Glu133-Lys136. Residues in yellow are demonstrated to have an effect on ligand binding affinity.[1]
Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled.
Fig. 3: Active sites linked to glucagon binding affinity located on ECL1 are labeled[1].
Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay
Fig. 4: Corticotropin-releasing factor 1 and glucagon receptors; Class B GPCRs with notable central splay
Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.
Fig. 5: Beta 2-adrenergic (class A) and glucagon receptors; showing an absence of central splay in Class A GPCRs.
Fig. 7: Active site buried deep in 7TMD of glucagon receptor.
Fig. 7: Active site buried deep in 7TMD of glucagon receptor.
Fig. 9: Location of anchoring pocket within central cavity.
Fig. 9: Location of anchoring pocket within central cavity.[1]
Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.
Fig. 10: Ballooned pocket functioning as anchoring site for glucagon residues 1-4.
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