Metabotropic glutamate receptor
From Proteopedia
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| - | <Structure load='1ewk' size='350' side='right' caption='Structure of the binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate and | + | <Structure load='1ewk' size='350' side='right' caption='Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions ([[1ewk]])' scene=' '/> |
| + | == Function == | ||
[[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | [[Metabotropic glutamate receptor|Metabotropic glutamate receptors]] are [[Glutamate Receptors|glutamate receptors]] that activate ion channels indirectly through a signaling cascade involving G proteins<ref>PMID:20716669</ref>. They are members of the large class of seven-transmembrane domain receptors, the [[G protein-coupled receptor|G protein-coupled receptors]]. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also [[Ligand Binding N-Terminal of Metabotropic Glutamate Receptors]]. | ||
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*[[Membrane proteins]] | *[[Membrane proteins]] | ||
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| + | == Structural highlights == | ||
| + | Glutamate is bound to GluR1 in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. | ||
==3D structures of metabotropic glutamate receptor == | ==3D structures of metabotropic glutamate receptor == | ||
Revision as of 09:17, 21 April 2016
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Contents |
Function
Metabotropic glutamate receptors are glutamate receptors that activate ion channels indirectly through a signaling cascade involving G proteins[1]. They are members of the large class of seven-transmembrane domain receptors, the G protein-coupled receptors. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also Ligand Binding N-Terminal of Metabotropic Glutamate Receptors.
- Metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 belong to group I and activate phospholipase C.
- Metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3 belong to group II and inhibit the cyclic AMP cascade.
- Metabotropic glutamate receptor 7 belongs to group III and inhibits adenylate cyclase activity.
Articles in Proteopedia concerning Toll-like Receptors include:
Structural highlights
Glutamate is bound to GluR1 in the crevice between the N-terminal and C-terminal domains[2].
3D structures of metabotropic glutamate receptor
Updated on 21-April-2016
See Also
Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease
References
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
- ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564
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Michal Harel, Alexander Berchansky, Wayne Decatur, Nikki Hunter
