Methylesterase
From Proteopedia
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'''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.<br /> | '''Methylesterase''' (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.<br /> | ||
| - | * '''CheB ME''' is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors<ref>PMID:7608964</ref>.<br /> | + | * '''CheB ME''' is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors<ref>PMID:7608964</ref>. See [[Chemotaxis protein]].<br /> |
* '''Pectin ME''' causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle<ref>PMID:11544130</ref>.<br /> | * '''Pectin ME''' causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle<ref>PMID:11544130</ref>.<br /> | ||
* '''Aclacinomycin ME''' modifies the aklavinone skeleton in the biosynthesis of anthracyclins in ''Streptomyces'' species<ref>PMID:11934504</ref>. <br /> | * '''Aclacinomycin ME''' modifies the aklavinone skeleton in the biosynthesis of anthracyclins in ''Streptomyces'' species<ref>PMID:11934504</ref>. <br /> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CheB methylesterase | ||
| - | |||
| - | **[[1chd]], [[1a2o]] – ME – ''Salmonella typhimurium''<br /> | ||
| - | **[[3sft]] – TmME catalytic domain – ''Thermotoga maritima''<br /> | ||
| - | **[[3t8y]] – TmME response regulator domain | ||
*Pectin methylesterase | *Pectin methylesterase | ||
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**[[4g4i]] – MtME (mutant)<br /> | **[[4g4i]] – MtME (mutant)<br /> | ||
**[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br /> | **[[4g4j]] – MtME (mutant) + 4-o-methyl-β-D-glucopyranuronate<br /> | ||
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| + | *CheB methylesterase see [[Chemotaxis protein]] | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:12, 25 April 2016
Methylesterase (ME) removes a methyl group from the Υ-glutamyl methyl esther residues of methyl-accepting chemotaxis proteins. ME participates in several metabolic pathways. Protein phosphatase ME is involved in the reversible methylation of protein phosphatase 2A which is active in cellular regulation.
- CheB ME is a phosphorylation-activated response regulator involved in reversible modification of bacterial chemotaxis receptors[1]. See Chemotaxis protein.
- Pectin ME causes demethylation of cell wall polygalactorunanas. It is involved in pectin digestion. The reaction products liberate frothing agents causing bloating in cattle[2].
- Aclacinomycin ME modifies the aklavinone skeleton in the biosynthesis of anthracyclins in Streptomyces species[3].
- Protein phosphatase ME is a key regulator of protein phosphatase 2A[4].
- 4-o-methyl-glucuronoyl ME has a significant role in biomass degradation[5].
3D structures of methylesterase
Updated on 25-April-2016
References
- ↑ Diaz-Lazcoz Y, Henaut A, Vigier P, Risler JL. Differential codon usage for conserved amino acids: evidence that the serine codons TCN were primordial. J Mol Biol. 1995 Jul 7;250(2):123-7. PMID:7608964 doi:http://dx.doi.org/10.1006/jmbi.1995.0363
- ↑ Micheli F. Pectin methylesterases: cell wall enzymes with important roles in plant physiology. Trends Plant Sci. 2001 Sep;6(9):414-9. PMID:11544130
- ↑ Wang Y, Niemi J, Mantsala P. Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products. FEMS Microbiol Lett. 2002 Feb 19;208(1):117-22. PMID:11934504
- ↑ Wandzioch E, Pusey M, Werda A, Bail S, Bhaskar A, Nestor M, Yang JJ, Rice LM. PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells. Cancer Res. 2014 Aug 15;74(16):4295-305. doi: 10.1158/0008-5472.CAN-13-3130. Epub, 2014 Jun 13. PMID:24928782 doi:http://dx.doi.org/10.1158/0008-5472.CAN-13-3130
- ↑ Spanikova S, Biely P. Glucuronoyl esterase--novel carbohydrate esterase produced by Schizophyllum commune. FEBS Lett. 2006 Aug 21;580(19):4597-601. Epub 2006 Jul 21. PMID:16876163 doi:http://dx.doi.org/10.1016/j.febslet.2006.07.033
