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Mitogen-activated protein kinase
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| - | {{STRUCTURE_1erk| right| PDB=1erk | SCENE=Mitogen-activated_protein_kinase/Cv/1 |CAPTION=Mitogen-activated protein kinase, [[1erk]] }} | ||
| - | [[Mitogen-activated protein kinase]] (MAPK) also known as Extracellular Signal-Regulated Kinase (ERK) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation. <br /> | + | <StructureSection load='2ojg' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''> |
| + | == Function == | ||
| + | [[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>. <br /> | ||
* '''MAPK1''' and '''MAPK3''' are activated in response to growth factors.<br /> | * '''MAPK1''' and '''MAPK3''' are activated in response to growth factors.<br /> | ||
* For '''MAPK2''' representations see [[Michael Roberts/BIOL115/ERK2]].<br /> | * For '''MAPK2''' representations see [[Michael Roberts/BIOL115/ERK2]].<br /> | ||
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* '''MAPK7''' is activated by stress stimuli.<br /> | * '''MAPK7''' is activated by stress stimuli.<br /> | ||
* '''MAPK8 (called also c-Jun N-terminal kinase 1 or JNK1), MAPK9, MAPK10''' (called also c-Jun N-terminal kinase 3 or JNK3), '''MAPK11, MAPK12, MAPK13, MAPK14''' are stress-activated.<br /> | * '''MAPK8 (called also c-Jun N-terminal kinase 1 or JNK1), MAPK9, MAPK10''' (called also c-Jun N-terminal kinase 3 or JNK3), '''MAPK11, MAPK12, MAPK13, MAPK14''' are stress-activated.<br /> | ||
| - | * '''MAPK11''' (also called p38-β MAPK), '''MAPK12''' (also called p38-γ MAPK), '''MAPK13''' (also called p38-δ MAPK), '''MAPK14''' (also called p38-α MAPK) | + | * '''MAPK11''' (also called '''p38-β MAPK'''), '''MAPK12''' (also called '''p38-γ MAPK'''), '''MAPK13''' (also called '''p38-δ MAPK'''), '''MAPK14''' (also called '''p38-α MAPK''') belongs to the class called p38 MAPK. |
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| + | == Relevance == | ||
| + | MAPK cascade is elevated in cancer cells, hence MAPK inhibitors are tested as potential cancer therapy. | ||
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| + | == Disease == | ||
| + | MAPK14 is associated with acquired hyperkeratosis and prostate transitional cell carcinoma. | ||
== 3D Structures of Mitogen-activated protein kinase == | == 3D Structures of Mitogen-activated protein kinase == | ||
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**[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br /> | **[[3uib]] – MAPK + inhibitor – ''Leishmania major''<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:23, 28 April 2016
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