Mitogen-activated protein kinase
From Proteopedia
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| - | + | <StructureSection load='2ojg' size='350' side='right' caption='Human MAPK1 complex with inhibitor and sulfate (PDB entry [[2ojg]])' scene=''> | |
| - | <StructureSection load='2ojg' size='350' side='right' caption='Human | + | |
== Function == | == Function == | ||
[[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>. <br /> | [[Mitogen-activated protein kinase]] (MAPK) also known as '''Extracellular Signal-Regulated Kinase (ERK)''' are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAPK is part of the MAPK cascade which consists of MAPK, [[Mitogen-activated protein kinase kinase|MAP2K]] and [[Mitogen-activated protein kinase kinase kinase|MAP3K]] which are activated by phosphorylation<ref>PMID:9069255</ref>. <br /> | ||
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== Disease == | == Disease == | ||
MAPK14 is associated with acquired hyperkeratosis and prostate transitional cell carcinoma. | MAPK14 is associated with acquired hyperkeratosis and prostate transitional cell carcinoma. | ||
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| + | == Structural highlights == | ||
| + | Inhibitors of MAPK bind in its ATP-binding site<ref>PMID:17300186</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of Mitogen-activated protein kinase == | == 3D Structures of Mitogen-activated protein kinase == | ||
Revision as of 07:35, 28 April 2016
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3D Structures of Mitogen-activated protein kinase
Updated on 28-April-2016
References
- ↑ Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997 Apr;9(2):180-6. PMID:9069255
- ↑ Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X. Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors. J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15. PMID:17300186 doi:http://dx.doi.org/10.1021/jm061381f
