Mitogen-activated protein kinase kinase kinase

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== Function ==
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[[Mitogen-activated protein kinase kinase kinase]] (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]<ref>PMID:9006902</ref>.
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[[Mitogen-activated protein kinase kinase kinase]] (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]].
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== Disease ==
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MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer.
== 3D Structures of Mitogen-activated protein kinase kinase ==
== 3D Structures of Mitogen-activated protein kinase kinase ==
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**[[4idt]], [[4idv]] - hMAP3K14 + inhibitor<br />
**[[4idt]], [[4idv]] - hMAP3K14 + inhibitor<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:00, 28 April 2016

Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase, 2clq

Template:STRUCTURE 2o2v

















Contents

Function

Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K[1].

Disease

MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer.

3D Structures of Mitogen-activated protein kinase kinase

Updated on 28-April-2016

References

  1. ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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