Mitogen-activated protein kinase kinase kinase
From Proteopedia
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| - | [[Image:2clq.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase kinase, [[2clq]]]] | + | [[Image:2clq.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, [[2clq]]]] |
{{STRUCTURE_2o2v| right| PDB=2o2v | SCENE= |CAPTION=Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey), [[2o2v]] }} | {{STRUCTURE_2o2v| right| PDB=2o2v | SCENE= |CAPTION=Mitogen-activated protein kinase kinase kinase 3 (green) complex with MAP2K5 PHOX domain (grey), [[2o2v]] }} | ||
Revision as of 09:03, 28 April 2016
Image:2clq.png
Crystal Structure of the Mitogen-activated protein kinase kinase kinase 5 kinase domain complex with staurosporine, 2clq
Contents |
Function
Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K[1].
Disease
MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer.
3D Structures of Mitogen-activated protein kinase kinase
Updated on 28-April-2016
References
- ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
