Muconate cycloisomerase
From Proteopedia
(Difference between revisions)
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**[[2zad]] – TmMCI – ''Thermotoga maritima''<br /> | **[[2zad]] – TmMCI – ''Thermotoga maritima''<br /> | ||
**[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br /> | **[[3ct2]] - PfMCI – ''Pseudomonas fluorescens''<br /> | ||
| - | **[[3dg3]] – MsMCI - ''Mycobacterium smegmatis'' | + | **[[3dg3]] – MsMCI - ''Mycobacterium smegmatis''<br /> |
| + | **[[3fcp]] – MCI – ''Klebsiella pneumoniae''<br /> | ||
*MCI complexes | *MCI complexes | ||
| Line 41: | Line 42: | ||
**[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br /> | **[[1q5n]] – MCI – ''Acinetobacter calcoaceticus''<br /> | ||
| - | **[[1re5]] - PbMCI | + | **[[1re5]] - PbMCI <br /> |
| + | **[[1jof]] – MCI – ''Neurospora crassa''<br /> | ||
| + | **[[2fel]], [[2fen]] – MCI – ''Agrobacterium tumefaciens''<br /> | ||
*'''Dipeptide epimerase''' | *'''Dipeptide epimerase''' | ||
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**[[3dfy]] – TmMCI<br /> | **[[3dfy]] – TmMCI<br /> | ||
**[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br /> | **[[3q45]], [[3q4d]] – MCI + Mg + dipeptide – ''Cytophaga hutchinsonii''<br /> | ||
| - | **[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus'' | + | **[[3rit]] - MCI + Mg + dipeptide – ''Methylococcus capsulatus''<br /> |
| + | **[[3jva]] – EfMCI + Mg – ''Enterococcus faecalis''<br /> | ||
| + | **[[3jw7]], [[3jzu]], [[3k1g]], [[3kum]] – EfMCI + Mg + dipeptide<br /> | ||
}} | }} | ||
== References == | == References == | ||
Revision as of 09:34, 1 May 2016
Muconate cycloisomerase (MCI) catalyzes the formation of muconolactone from cis,cis-muconate. It is part of the B-ketoadipate pathway in the metabolism of aromatic compounds[1]. MCI breaks down lignin-derived catechol and protocatechuate.
- Chloromuconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to cis,cis-butadiene-1,2,4-tricarboxylate [2].
- 3-carboxy-cis,cis-muconate cycloisomerase catalyzes the reversible conversion of 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-chloro-cis,cis-muconate[3].
3D Structures of muconate cycloisomerase
Updated on 01-May-2016
References
- ↑ Vollmer MD, Hoier H, Hecht HJ, Schell U, Groning J, Goldman A, Schlomann M. Substrate specificity of and product formation by muconate cycloisomerases: an analysis of wild-type enzymes and engineered variants. Appl Environ Microbiol. 1998 Sep;64(9):3290-9. PMID:9726873
- ↑ Schmidt E, Knackmuss HJ. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem J. 1980 Oct 15;192(1):339-47. PMID:7305906
- ↑ Ornston LN. The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. II. Enzymes of the protocatechuate pathway. J Biol Chem. 1966 Aug 25;241(16):3787-94. PMID:5916392
