NAD(P) transhydrogenase

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* Domain II is a membrane-spanning domain.<br />
* Domain II is a membrane-spanning domain.<br />
* Domain III binds NADP(+)/NADPH.<br />
* Domain III binds NADP(+)/NADPH.<br />
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PTH is composed of 2 subunits. Subunit beta contains domain III and part of II.
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PTH is composed of 2 subunits. Subunit β contains domain III and part of II. The active site of PTH contains NAD in domain I and NADP in domain III<ref>PMID:15323555</ref>.
</StructureSection>
</StructureSection>

Revision as of 08:28, 5 May 2016

Structure of PTH domains I (grey and green) and III (pink) complex with NAD and NADP (PDB entry 1u28)

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3D structures of NAD(P) transhydrogenase

Updated on 05-May-2016

References

  1. Jackson JB. Proton translocation by transhydrogenase. FEBS Lett. 2003 Jun 12;545(1):18-24. PMID:12788487
  2. Mather OC, Singh A, van Boxel GI, White SA, Jackson JB. Active-site conformational changes associated with hydride transfer in proton-translocating transhydrogenase. Biochemistry. 2004 Aug 31;43(34):10952-64. PMID:15323555 doi:10.1021/bi0497594

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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