Neuraminidase

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{{STRUCTURE_3nss| PDB=3nss | SIZE=350| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with Ca+2 (green) and acetate, [[3nss]] }}
{{STRUCTURE_3nss| PDB=3nss | SIZE=350| SCENE= |right|CAPTION=Glycosylated Influenza virus neuraminidase complex with Ca+2 (green) and acetate, [[3nss]] }}
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== Function ==
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'''Neuraminidase''' (NAN) cleaves the glycosidic bonds of neuraminic acid. The viral NAN is a drug target for prevention of influenza.
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'''Neuraminidase''' (NAN) cleaves the glycosidic bonds of neuraminic acid<ref>PMID:15507653</ref>. <br />
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*'''endo-neuraminidase''' is a phage neuraminidase which cleaves α-2,8-polysialic acid<ref>PMID:4055897</ref>. <br />
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*'''Pseudaminidase''' is a ''Pseudomonas aeruginosa'' neuraminidase. <br />
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*'''Trans-sialidase''' transfers sialic acid from ''Trypanosoma cruzi'' to a host cell<ref>PMID:8405811</ref>. <br />
See also<br />
See also<br />
*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />
*[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]<br />
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*[[Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose]]<br />
*[[Carbohydrate binding domain from Streptococcus pneumoniae NanA sialidase complexed with 3'-sialyllactose]]<br />
*[[Treatments:Neuraminidase Inhibitor Pharmacokinetics References]]<br />.
*[[Treatments:Neuraminidase Inhibitor Pharmacokinetics References]]<br />.
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== Relevance ==
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The viral NAN is a drug target for prevention of influenza<ref>PMID:19768409</ref>. In Chagas disease trans-sialidase on the surface of ''Trypanosoma cruzi'' participate in host-parasite interactions and mediate the initial stages of the invasion of the host cell<ref>PMID:7826016</ref>.
==3D structures of Neuraminidase==
==3D structures of Neuraminidase==
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:32, 8 May 2016

Template:STRUCTURE 3nss

Contents

Function

Neuraminidase (NAN) cleaves the glycosidic bonds of neuraminic acid[1].

  • endo-neuraminidase is a phage neuraminidase which cleaves α-2,8-polysialic acid[2].
  • Pseudaminidase is a Pseudomonas aeruginosa neuraminidase.
  • Trans-sialidase transfers sialic acid from Trypanosoma cruzi to a host cell[3].

See also

For other inhibitors see

Relevance

The viral NAN is a drug target for prevention of influenza[4]. In Chagas disease trans-sialidase on the surface of Trypanosoma cruzi participate in host-parasite interactions and mediate the initial stages of the invasion of the host cell[5].

3D structures of Neuraminidase

Updated on 08-May-2016

References

  1. ↑ Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol. 2004 Nov;78(22):12665-7. PMID:15507653 doi:http://dx.doi.org/10.1128/JVI.78.22.12665-12667.2004
  2. ↑ Rutishauser U, Watanabe M, Silver J, Troy FA, Vimr ER. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. J Cell Biol. 1985 Nov;101(5 Pt 1):1842-9. PMID:4055897
  3. ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
  4. ↑ Sylte MJ, Suarez DL. Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 2009;333:227-41. doi: 10.1007/978-3-540-92165-3_12. PMID:19768409 doi:http://dx.doi.org/10.1007/978-3-540-92165-3_12
  5. ↑ Schenkman S, Eichinger D, Pereira ME, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol. 1994;48:499-523. PMID:7826016 doi:http://dx.doi.org/10.1146/annurev.mi.48.100194.002435

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