Neuraminidase
From Proteopedia
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<StructureSection load='2ht7' size='350' side='right' caption='H5N1 avian nfluenza virus neuraminidase complex with Tamiflu (PDB entry [[2ht7]])' scene=''> | <StructureSection load='2ht7' size='350' side='right' caption='H5N1 avian nfluenza virus neuraminidase complex with Tamiflu (PDB entry [[2ht7]])' scene=''> | ||
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The viral NAN is a drug target for prevention of influenza<ref>PMID:19768409</ref>. In Chagas disease trans-sialidase on the surface of ''Trypanosoma cruzi'' participate in host-parasite interactions and mediate the initial stages of the invasion of the host cell<ref>PMID:7826016</ref>. | The viral NAN is a drug target for prevention of influenza<ref>PMID:19768409</ref>. In Chagas disease trans-sialidase on the surface of ''Trypanosoma cruzi'' participate in host-parasite interactions and mediate the initial stages of the invasion of the host cell<ref>PMID:7826016</ref>. | ||
| + | == Structural highlights == | ||
| + | The active site of NAN contains the influenza drug Tamiflu<ref>PMID:16915235</ref>. | ||
| + | </StructureSection> | ||
==3D structures of Neuraminidase== | ==3D structures of Neuraminidase== | ||
Revision as of 09:54, 8 May 2016
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3D structures of Neuraminidase
Updated on 08-May-2016
References
- ↑ Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol. 2004 Nov;78(22):12665-7. PMID:15507653 doi:http://dx.doi.org/10.1128/JVI.78.22.12665-12667.2004
- ↑ Rutishauser U, Watanabe M, Silver J, Troy FA, Vimr ER. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. J Cell Biol. 1985 Nov;101(5 Pt 1):1842-9. PMID:4055897
- ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
- ↑ Sylte MJ, Suarez DL. Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 2009;333:227-41. doi: 10.1007/978-3-540-92165-3_12. PMID:19768409 doi:http://dx.doi.org/10.1007/978-3-540-92165-3_12
- ↑ Schenkman S, Eichinger D, Pereira ME, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol. 1994;48:499-523. PMID:7826016 doi:http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
- ↑ Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235 doi:http://dx.doi.org/10.1038/nature05114
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