Sandbox WWC7
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='4OE1' size='350' side='right' caption=''PPR10 structure isolated from ''Zea Mays'' (PDB code [[4OE1]])' > |
| - | + | Pentatricopeptide repeat (PPR) proteins are a family of sequence specific RNA-binding proteins which participate in organelle RNA metabolism. Although the mechanisms of RNA binding and the functions of PPR proteins are not fully understood, PPR proteins are thought to assist in RNA editing,<ref>PMID:17015439</ref> translation,<ref name = "translation">DOI:10.1073/pnas.1012076108</ref> and organelle biogenesis.<ref>PMID:15269332</ref> They make up the majority of RNA-binding factors in plant organelles. PPR proteins are characterized by a series of tandem-repeat amino acid consensus sequences which form α-helix hairpins. These hairpin structures accumulate to form a α-solenoid tertiary structure. PPR proteins belong to one of two classes: P-class and PLS-class, with the P-class containing 35 amino acid repeats and the PLS-class containing 31-36 amino acid repeats. PPR10 is a well-characterized P-class PPR protein found in the chloroplast of ''Zea mays''.<ref name = "translation"/> | |
| - | Pentatricopeptide repeat (PPR) proteins are a family of sequence specific RNA-binding proteins which participate in organelle RNA metabolism. Although the mechanisms of RNA binding and the functions of PPR proteins are not fully understood, PPR proteins are thought to assist in RNA editing | + | |
==Function== | ==Function== | ||
In the ''Zea mays'' plastid, PPR10 binds specifically to the RNA oligonucleotides ATPH (17 nucleotides) and SPAJ (18 nucleotides) where it has been shown to shield the transcripts from ribonucleases. In addition to stabilizing these RNA sequences, PPR10 increases the rate at which they are translated. | In the ''Zea mays'' plastid, PPR10 binds specifically to the RNA oligonucleotides ATPH (17 nucleotides) and SPAJ (18 nucleotides) where it has been shown to shield the transcripts from ribonucleases. In addition to stabilizing these RNA sequences, PPR10 increases the rate at which they are translated. | ||
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| + | ==Mechanism== | ||
| + | ''Zea mays'' works by. . . | ||
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| + | ==Synthetic Applications== | ||
| + | There is potential. . . | ||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
Revision as of 17:25, 8 May 2016
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