Neuroglobin

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{{STRUCTURE_3gk9| PDB=3gk9 | SIZE=400| SCENE= |right|CAPTION=Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]] }}
{{STRUCTURE_3gk9| PDB=3gk9 | SIZE=400| SCENE= |right|CAPTION=Mouse neuroglobin showing the heme and complexed with sulfate and Xe [[3gk9]] }}
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== Function ==
'''Neuroglobin''' (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly. It increases oxygen availability in the brain. It is a monomer containing a heme group<ref>PMID:15298922</ref>.
'''Neuroglobin''' (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly. It increases oxygen availability in the brain. It is a monomer containing a heme group<ref>PMID:15298922</ref>.
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== Relevance ==
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NGB may influence the course of Alzhheimer's disease<ref>PMID:23648513</ref>.
== 3D Structures of Neuroglobin ==
== 3D Structures of Neuroglobin ==

Revision as of 07:42, 9 May 2016

Template:STRUCTURE 3gk9

Contents

Function

Neuroglobin (NGB) is involved in cellular oxygen homeostasis. It binds oxygen reversibly. It increases oxygen availability in the brain. It is a monomer containing a heme group[1].

Relevance

NGB may influence the course of Alzhheimer's disease[2].

3D Structures of Neuroglobin

Updated on 09-May-2016

3gk9, 3gkt, 2vry, 1q1f, 4mu5, 4nzi, 4o1t, 4o4t – mNGB (mutant) – mouse
3gln, 1w92, 4o2g, 4o35 – mNGB (mutant) + CO
4o4z – mNGB (mutant) + N2O
1oj6 – hNGB (mutant) - human
4mpm – hNGB
4b4y – NGB – Symsagittifera roscoffensis

References

  1. ↑ Uzan J, Dewilde S, Burmester T, Hankeln T, Moens L, Hamdane D, Marden MC, Kiger L. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Biophys J. 2004 Aug;87(2):1196-204. PMID:15298922 doi:http://dx.doi.org/10.1529/biophysj.104.042168
  2. ↑ Sun F, Mao X, Xie L, Greenberg DA, Jin K. Neuroglobin protein is upregulated in Alzheimer's disease. J Alzheimers Dis. 2013;36(4):659-63. doi: 10.3233/JAD-130323. PMID:23648513 doi:http://dx.doi.org/10.3233/JAD-130323

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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