4pk4

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==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==
==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==
<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pfo|4pfo]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pfo|4pfo]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://pdbe.org/4pk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fundamental to cellular processes are directional movements driven by molecular motors. A common theme for these and other molecular machines driven by ATP is that controlled release of hydrolysis products is essential for using the chemical energy efficiently. Mechanochemical transduction by myosin motors on actin is coupled to unknown structural changes that result in the sequential release of inorganic phosphate (Pi) and MgADP. We present here a myosin structure possessing an actin-binding interface and a tunnel (back door) that creates an escape route for Pi with a minimal rotation of the myosin lever arm that drives movements. We propose that this state represents the beginning of the powerstroke on actin and that Pi translocation from the nucleotide pocket triggered by actin binding initiates myosin force generation. This elucidates how actin initiates force generation and movement and may represent a strategy common to many molecular machines.
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How actin initiates the motor activity of Myosin.,Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025. Epub 2015 , Apr 30. PMID:25936506<ref>PMID:25936506</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4pk4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Revision as of 15:48, 10 May 2016

Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4

4pk4, resolution 2.78Å

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