1hiw
From Proteopedia
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|PDB= 1hiw |SIZE=350|CAPTION= <scene name='initialview01'>1hiw</scene>, resolution 2.3Å | |PDB= 1hiw |SIZE=350|CAPTION= <scene name='initialview01'>1hiw</scene>, resolution 2.3Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hiw OCA], [http://www.ebi.ac.uk/pdbsum/1hiw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hiw RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Sundquist, W I.]] | [[Category: Sundquist, W I.]] | ||
[[Category: Worthylake, D.]] | [[Category: Worthylake, D.]] | ||
| - | [[Category: SO4]] | ||
[[Category: hiv-1]] | [[Category: hiv-1]] | ||
[[Category: hiv-1 ma]] | [[Category: hiv-1 ma]] | ||
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[[Category: p17]] | [[Category: p17]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:05:43 2008'' |
Revision as of 18:05, 30 March 2008
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| , resolution 2.3Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TRIMERIC HIV-1 MATRIX PROTEIN
Overview
The human immunodeficiency virus type 1 (HIV-1) matrix protein forms a structural shell associated with the inner viral membrane and performs other essential functions throughout the viral life cycle. The crystal structure of the HIV-1 matrix protein, determined at 2.3 angstrom resolution, reveals that individual matrix molecules are composed of five major helices capped by a three-stranded mixed beta-sheet. Unexpectedly, the protein assembles into a trimer in three different crystal lattices, burying 1880 angstrom2 of accessible surface area at the trimer interfaces. Trimerization appears to create a large, bipartite membrane binding surface in which exposed basic residues could cooperate with the N-terminal myristoyl groups to anchor the protein on the acidic inner membrane of the virus.
About this Structure
1HIW is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.
Reference
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly., Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104. PMID:8610175
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