5b0o
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the FliH-FliI complex== | |
| + | <StructureSection load='5b0o' size='340' side='right' caption='[[5b0o]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5b0o]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B0O FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2dpy|2dpy]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b0o OCA], [http://pdbe.org/5b0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b0o RCSB], [http://www.ebi.ac.uk/pdbsum/5b0o PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FLII_SALTY FLII_SALTY]] Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage. [[http://www.uniprot.org/uniprot/FLIH_SALTY FLIH_SALTY]] Needed for flagellar regrowth and assembly. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | FliI and FliJ form the FliI6FliJ ATPase complex of the bacterial flagellar export apparatus, a member of the type III secretion system. The FliI6FliJ complex is structurally similar to the alpha3beta3gamma complex of F1-ATPase. The FliH homodimer binds to FliI to connect the ATPase complex to the flagellar base, but the details are unknown. Here we report the structure of the homodimer of a C-terminal fragment of FliH (FliHC2) in complex with FliI. FliHC2shows an unusually asymmetric homodimeric structure that markedly resembles the peripheral stalk of the A/V-type ATPases. The FliHC2-FliI hexamer model reveals that the C-terminal domains of the FliI ATPase face the cell membrane in a way similar to the F/A/V-type ATPases. We discuss the mechanism of flagellar ATPase complex formation and a common origin shared by the type III secretion system and the F/A/V-type ATPases. | ||
| - | + | Insight into the flagella type III export revealed by the complex structure of the type III ATPase and its regulator.,Imada K, Minamino T, Uchida Y, Kinoshita M, Namba K Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3633-8. doi:, 10.1073/pnas.1524025113. Epub 2016 Mar 16. PMID:26984495<ref>PMID:26984495</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 5b0o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Imada, K]] | [[Category: Imada, K]] | ||
| - | [[Category: | + | [[Category: Kinoshita, M]] |
[[Category: Minamino, T]] | [[Category: Minamino, T]] | ||
[[Category: Namba, K]] | [[Category: Namba, K]] | ||
| - | [[Category: | + | [[Category: Uchida, Y]] |
| + | [[Category: Atpase]] | ||
| + | [[Category: Bacterial flagellum]] | ||
| + | [[Category: Hydrolase-motor protein complex]] | ||
| + | [[Category: Peripheral stalk]] | ||
| + | [[Category: Type iii secretion]] | ||
Revision as of 18:21, 10 May 2016
Structure of the FliH-FliI complex
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