3jc9
From Proteopedia
(Difference between revisions)
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| - | ''' | + | {{Large structure}} |
| + | ==Architectural model of the type IVa pilus machine in a non-piliated state== | ||
| + | <StructureSection load='3jc9' size='340' side='right' caption='[[3jc9]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3jc9]] is a 79 chain structure with sequence from [http://en.wikipedia.org/wiki/Myxococcus_xanthus_dk_1622 Myxococcus xanthus dk 1622]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JC9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jc8|3jc8]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jc9 OCA], [http://pdbe.org/3jc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jc9 RCSB], [http://www.ebi.ac.uk/pdbsum/3jc9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | {{Large structure}} | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Type IVa pili are filamentous cell surface structures observed in many bacteria. They pull cells forward by extending, adhering to surfaces, and then retracting. We used cryo-electron tomography of intact Myxococcus xanthus cells to visualize type IVa pili and the protein machine that assembles and retracts them (the type IVa pilus machine, or T4PM) in situ, in both the piliated and nonpiliated states, at a resolution of 3 to 4 nanometers. We found that T4PM comprises an outer membrane pore, four interconnected ring structures in the periplasm and cytoplasm, a cytoplasmic disc and dome, and a periplasmic stem. By systematically imaging mutants lacking defined T4PM proteins or with individual proteins fused to tags, we mapped the locations of all 10 T4PM core components and the minor pilins, thereby providing insights into pilus assembly, structure, and function. | ||
| - | + | Architecture of the type IVa pilus machine.,Chang YW, Rettberg LA, Treuner-Lange A, Iwasa J, Sogaard-Andersen L, Jensen GJ Science. 2016 Mar 11;351(6278):aad2001. doi: 10.1126/science.aad2001. Epub 2016, Mar 10. PMID:26965631<ref>PMID:26965631</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 3jc9" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| - | [[Category: Chang, Y | + | <references/> |
| - | [[Category: Jensen, G | + | __TOC__ |
| - | [[Category: Rettberg, L | + | </StructureSection> |
| + | [[Category: Myxococcus xanthus dk 1622]] | ||
| + | [[Category: Chang, Y W]] | ||
| + | [[Category: Jensen, G J]] | ||
| + | [[Category: Rettberg, L A]] | ||
| + | [[Category: Membrane channel]] | ||
| + | [[Category: Motor]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Pilus]] | ||
| + | [[Category: Ring]] | ||
Revision as of 18:38, 10 May 2016
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Architectural model of the type IVa pilus machine in a non-piliated state
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