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5f8s

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'''Unreleased structure'''
 
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The entry 5f8s is ON HOLD until Paper Publication
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==Crystal structure of a Crenomytilus grayanus lectin==
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<StructureSection load='5f8s' size='340' side='right' caption='[[5f8s]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f8s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F8S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f8w|5f8w]], [[5f8y|5f8y]], [[5f90|5f90]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8s OCA], [http://pdbe.org/5f8s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8s RCSB], [http://www.ebi.ac.uk/pdbsum/5f8s PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this study, we report the structure and function of a lectin from the sea mollusk Crenomytilus grayanus collected from the sublittoral zone of Peter the Great Bay of the Sea of Japan. The crystal structure of C. grayanus lectin (CGL) was solved to a resolution of 1.08 A, revealing a beta-trefoil fold that dimerizes into a dumbbell-shaped quaternary structure. Analysis of the crystal CGL structures bound to galactose, galactosamine, and globotriose Gb3 indicated that each CGL can bind three ligands through a carbohydrate-binding motif involving an extensive histidine- and water-mediated hydrogen bond network. CGL binding to Gb3 is further enhanced by additional side-chain-mediated hydrogen bonds in each of the three ligand-binding sites. NMR titrations revealed that the three binding sites have distinct microscopic affinities toward galactose and galactosamine. Cell viability assays showed that CGL recognizes Gb3 on the surface of breast cancer cells, leading to cell death. Our findings suggest the use of this lectin in cancer diagnosis and treatment.
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Authors: Liao, J.-H., Huang, K.-F., Tu, I.-F., Lee, I.-M., Wu, S.-H.
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A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3.,Liao JH, Chien CT, Wu HY, Huang KF, Wang I, Ho MR, Tu IF, Lee IM, Li W, Shih YL, Wu CY, Lukyanov PA, Hsu ST, Wu SH J Am Chem Soc. 2016 Apr 13;138(14):4787-95. doi: 10.1021/jacs.6b00111. Epub 2016 , Apr 1. PMID:27010847<ref>PMID:27010847</ref>
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Description: Crystal structure of a Crenomytilus grayanus lectin
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Wu, S.-H]]
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<div class="pdbe-citations 5f8s" style="background-color:#fffaf0;"></div>
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[[Category: Lee, I.-M]]
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== References ==
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[[Category: Huang, K.-F]]
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<references/>
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[[Category: Liao, J.-H]]
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__TOC__
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[[Category: Tu, I.-F]]
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</StructureSection>
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[[Category: Huang, K F]]
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[[Category: Lee, I M]]
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[[Category: Liao, J H]]
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[[Category: Tu, I F]]
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[[Category: Wu, S H]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]

Revision as of 19:27, 10 May 2016

Crystal structure of a Crenomytilus grayanus lectin

5f8s, resolution 1.08Å

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