Sandbox WWC5
From Proteopedia
| Line 6: | Line 6: | ||
'''Growth hormone releasing hormone''' (GHRH) is a secretory neurohormone that causes growth hormone to be released from the pituitary gland. It is naturally produced in the arcuate nucleus of the hypothalamus. The [[hormone]] is produced as a 44 amino acid peptide hormone, and first appears in the hypothalamus between 18 and 29 weeks of gestation, corresponding to the initial production of growth hormone by the fetus <ref>PMID:6344776</ref>. Growth hormone is required for normal fetal and post fetal development, including bone growth and the regulation of protein production and the metabolism of lipids and carbohydrates <ref>PMID:15525469</ref>. | '''Growth hormone releasing hormone''' (GHRH) is a secretory neurohormone that causes growth hormone to be released from the pituitary gland. It is naturally produced in the arcuate nucleus of the hypothalamus. The [[hormone]] is produced as a 44 amino acid peptide hormone, and first appears in the hypothalamus between 18 and 29 weeks of gestation, corresponding to the initial production of growth hormone by the fetus <ref>PMID:6344776</ref>. Growth hormone is required for normal fetal and post fetal development, including bone growth and the regulation of protein production and the metabolism of lipids and carbohydrates <ref>PMID:15525469</ref>. | ||
| - | == | + | ==Structural Features== |
The GHRH receptor gene is expressed in the pituitary as a G-coupled receptor that binds GHRH, resulting in the release of growth hormone <ref>PMID:10429879</ref>. The figure below and to the left is the extracellular domain of the GHRH receptor. | The GHRH receptor gene is expressed in the pituitary as a G-coupled receptor that binds GHRH, resulting in the release of growth hormone <ref>PMID:10429879</ref>. The figure below and to the left is the extracellular domain of the GHRH receptor. | ||
<Structure load='2XDG' size='350' frame='true' align='left' caption='GHRH Receptor ' scene='Insert optional scene name here' /> | <Structure load='2XDG' size='350' frame='true' align='left' caption='GHRH Receptor ' scene='Insert optional scene name here' /> | ||
| Line 47: | Line 47: | ||
| - | == | + | ==Function and Pathway== |
[[Image:GHRH Signaling.jpg]] | [[Image:GHRH Signaling.jpg]] | ||
Revision as of 21:02, 10 May 2016
Contents |
Growth Hormone Releasing Hormone
|
Introduction
Growth hormone releasing hormone (GHRH) is a secretory neurohormone that causes growth hormone to be released from the pituitary gland. It is naturally produced in the arcuate nucleus of the hypothalamus. The hormone is produced as a 44 amino acid peptide hormone, and first appears in the hypothalamus between 18 and 29 weeks of gestation, corresponding to the initial production of growth hormone by the fetus [1]. Growth hormone is required for normal fetal and post fetal development, including bone growth and the regulation of protein production and the metabolism of lipids and carbohydrates [2].
Structural Features
The GHRH receptor gene is expressed in the pituitary as a G-coupled receptor that binds GHRH, resulting in the release of growth hormone [3]. The figure below and to the left is the extracellular domain of the GHRH receptor.
|
Function and Pathway
This image shows the signalling pathway of GHRH causing the release of growth hormone [4]
Medical Implications
References
- ↑ Chawla RK, Parks JS, Rudman D. Structural variants of human growth hormone: biochemical, genetic, and clinical aspects. Annu Rev Med. 1983;34:519-47. PMID:6344776 doi:http://dx.doi.org/10.1146/annurev.me.34.020183.002511
- ↑ Tang SS, Zhang JH, Du MH, Wu J, Liu JJ. Construction and activity of a novel GHRH analog, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys. Acta Pharmacol Sin. 2004 Nov;25(11):1464-70. PMID:15525469
- ↑ Gaylinn BD. Molecular and cell biology of the growth hormone-releasing hormone receptor. Growth Horm IGF Res. 1999 Apr;9 Suppl A:37-44. PMID:10429879
- ↑ https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details?pwid=199
