1htm
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1htm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1htm OCA], [http://www.ebi.ac.uk/pdbsum/1htm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1htm RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HTM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1HTM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. The following page contains interesting information on the relation of 1HTM with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HTM OCA]. |
==Reference== | ==Reference== | ||
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8072525 8072525] | Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8072525 8072525] | ||
| + | [[Category: Bacteria]] | ||
[[Category: Hemagglutinin]] | [[Category: Hemagglutinin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Uncultured beta proteobacterium umtra-608]] | ||
[[Category: Bullough, P A.]] | [[Category: Bullough, P A.]] | ||
[[Category: Hughson, F M.]] | [[Category: Hughson, F M.]] | ||
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[[Category: influenza virus hemagglutinin]] | [[Category: influenza virus hemagglutinin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:16 2008'' |
Revision as of 18:10, 30 March 2008
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| , resolution 2.5Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF INFLUENZA HAEMAGGLUTININ AT THE PH OF MEMBRANE FUSION
Overview
Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.
About this Structure
1HTM is a Protein complex structure of sequences from Bacteria. The following page contains interesting information on the relation of 1HTM with [Hemagglutinin]. Full crystallographic information is available from OCA.
Reference
Structure of influenza haemagglutinin at the pH of membrane fusion., Bullough PA, Hughson FM, Skehel JJ, Wiley DC, Nature. 1994 Sep 1;371(6492):37-43. PMID:8072525
Page seeded by OCA on Sun Mar 30 21:10:16 2008
